Taapsee Pannu started her acting career in 2010 with K. Raghavendra Rao’s Jhummandi Naadam. The movie co-starring Manchu Manoj Kumar and Mohan Babu opened to mixed reviews and was an average earner. The following year, the actress made her Tamil film debut with the critically acclaimed Aadukalam directed by Vetrimaran. The movie also featuring Dhanush in the lead role was set in the town of Madurai and revolved around cockfights. Although Taapsee was a newbie in the Tamil film industry then, she essayed the role of an Anglo-Indian girl with utmost conviction and the movie went on to win six National Film Awards at the 58th National Film Awards.
After the much success of Aadukalam, the actress returned to the Telugu film industry with Vastadu Naa Raju, which released in February 2011. The movie co-starring Vishnu Manchu and Prakash Raj was an average hit. She next appeared in her maiden Malayalam film opposite superstar Mammootty and Nadhiya in Doubles. The movie directed by Sohan Seenulal fell short of the audience expectations and got an average reception at the box-office. The film was later dubbed in Hindi with the same title. Her next film in 2011 was Mr. Perfect alongside Kajal Aggarwal and Prabhas, which was a moderate success. Taapsee’s other releases of the year Veera and Mogudu failed to impress the audience as well as the critics.
In 2013, the actress starred in a Telugu-Tamil bilingual film titled Gundello Godari and Maranthen Mannithen directed by Kumar Nagendra and produced by actress Lakshmi Manchu. The Telugu version of the movie got a positive response at the box-office and it was also nominated for the Best film at the International Indian Film festival in South Africa. Her other Telugu release of the year was Meher Ramesh’s Shadow, which also had Daggubatti Venkatesh in the lead role. The movie got mixed critical reception and was an average earner. In the same year, she made her debut in Bollywood with David Dhawan’s comedy film titled Chashme Baddoor with Ali Zafar, Siddharth and Divyendu Sharma in the lead roles. The movie, which was the remake of the 1981 film with the same title got positive reviews and was a commercial success. Her last movie of the year was an action-thriller Tamil film titled Arrambam alongside Ajith Kumar and Arya. The movie was a commercial and critical hit and for her brilliant performance in the movie, Taapsee Pannu won the Most Enthusiastic Performer-Female Award at the 2014 Edison Awards.
With no releases to her name in 2014, Taapsee Pannu made a smashing comeback in the critically acclaimed Hindi movie, Baby directed by Neeraj Pandey. The film, which also starred Akshay Kumar, Rana Daggubati, Anupam Kher and Danny Denzongpa had the actress playing the role of an undercover agent. Taapsee had two more Tamil film releases in the same year viz. The horror comedy Kanchana 2 along side Raghava Lawrence and Vai Raja Vai directed by Aishwarya Dhanush where she appeared in a guest role. In 2016, Taapsee was seen in Shoojit Sircar’s drama-thriller alongside Amitabh Bachchan, Pink, which went on to become, both, a commercial and critical success. Following the success of her 2016 project, Taapsee signed a number of projects for 2017 such as RunningShaadi.com, The Ghazi Attack, Naam Shabana, and Judwaa 2.